A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC

BCI is safe and feasible. In addition, we provide preliminary evidence that at higher dose levels there is a systemic immune response consistent with a cytotoxic profile. Further immune analyses will determine the potential of BCI as an adjunctive therapy in combination with immune checkpoint inhibition in NSCLC treatment.

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Publication Details

Journal
JTO Clinical and Research Reports
Published
2025-05-15
DOI
https://doi.org/10.1016/j.jtocrr.2025.100849
Primary Topic
Lung Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC

Antonio Vélez García‐Nieto, K. Krolikowski, Vivek Murthy, Leopoldo N. Segal et al.
1 links
JTO Clinical and Research Reports
Lung Cancer Diagnosis and Treatment
article

A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC

Antonio Vélez García‐Nieto, K. Krolikowski, Vivek Murthy, Leopoldo N. Segal, Samaan Rafeq, Daniel H. Sterman, Katherine Gershner, Andrew DeMaio, Jun-Chieh James Tsay, Sara Borghi, S. Roldán, Aristotelis Tsirigos, Fang Zhou, Kendrew Wong, Benjamin Kwok, Rosemary Schluger, Ray Pillai, Francisco Adalberto do Nascimento Paz, J.L. Bessich, Fares Darawshy, Destiny Collazo, Isaac Laniado, Harvey I. Pass, Alena Lukovnikova, M. Blaisdell, Liu Y, Judy Gong, Yonghua Li
article en

Abstract

BCI is safe and feasible. In addition, we provide preliminary evidence that at higher dose levels there is a systemic immune response consistent with a cytotoxic profile. Further immune analyses will determine the potential of BCI as an adjunctive therapy in combination with immune checkpoint inhibition in NSCLC treatment.

JTO Clinical and Research ReportsVol. 6(8)
Hebrew University of Jerusalem (IL), Hadassah Medical Center (IL), VA NY Harbor Healthcare System (US), NYU Langone Health (US), Wake Forest University (US), New York University (US)
National Cancer Institute
Good health and well-being
Openalex Percentile: Top 82%
Lung Cancer Diagnosis and Treatment
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