A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC
BCI is safe and feasible. In addition, we provide preliminary evidence that at higher dose levels there is a systemic immune response consistent with a cytotoxic profile. Further immune analyses will determine the potential of BCI as an adjunctive therapy in combination with immune checkpoint inhibition in NSCLC treatment.
Authors
- Antonio Vélez García‐Nieto (ORCID: https://orcid.org/0000-0001-8013-7530)
- K. Krolikowski
- Vivek Murthy (ORCID: https://orcid.org/0000-0003-3935-671X)
- Leopoldo N. Segal (ORCID: https://orcid.org/0000-0003-3559-9431)
- Samaan Rafeq (ORCID: https://orcid.org/0000-0003-1573-1896)
- Daniel H. Sterman (ORCID: https://orcid.org/0009-0004-0170-2722)
- Katherine Gershner
- Andrew DeMaio (ORCID: https://orcid.org/0000-0001-8338-0974)
- Jun-Chieh James Tsay (ORCID: https://orcid.org/0000-0002-2282-2510)
- Sara Borghi (ORCID: https://orcid.org/0000-0001-5473-3240)
- S. Roldán
- Aristotelis Tsirigos (ORCID: https://orcid.org/0000-0002-7512-8477)
- Fang Zhou (ORCID: https://orcid.org/0000-0002-5542-2994)
- Kendrew Wong
- Benjamin Kwok (ORCID: https://orcid.org/0000-0002-6331-2779)
- Rosemary Schluger
- Ray Pillai (ORCID: https://orcid.org/0000-0002-8335-3463)
- Francisco Adalberto do Nascimento Paz (ORCID: https://orcid.org/0000-0001-6697-1705)
- J.L. Bessich (ORCID: https://orcid.org/0000-0003-3202-4085)
- Fares Darawshy (ORCID: https://orcid.org/0000-0003-0177-908X)
- Destiny Collazo (ORCID: https://orcid.org/0009-0001-3898-0695)
- Isaac Laniado
- Harvey I. Pass (ORCID: https://orcid.org/0000-0003-3222-3471)
- Alena Lukovnikova
- M. Blaisdell
- Liu Y (ORCID: https://orcid.org/0000-0003-2030-643X)
- Judy Gong
- Yonghua Li
Institutions
- Hebrew University of Jerusalem (IL)
- Hadassah Medical Center (IL)
- VA NY Harbor Healthcare System (US)
- NYU Langone Health (US)
- Wake Forest University (US)
- New York University (US)
Publication Details
- Journal
- JTO Clinical and Research Reports
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1016/j.jtocrr.2025.100849
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cancer Institute