A Rare Presentation of Hypocalcaemia-Induced Seizure Secondary to Late-Onset Post-Thyroidectomy Complication

We report a rare case of late-onset hypocalcaemia presenting with seizure in a female patient, occurring approximately 25 years after a total thyroidectomy. Initial investigations ruled out intracranial pathology, and biochemical analysis confirmed severe hypocalcaemia. The patient responded to intravenous calcium gluconate infusion, with subsequent stabilisation on oral calcium therapy. Notably, the patient had been non-compliant with long-term calcium supplementation. This report underscores that chronic hypocalcaemia can manifest with acute neurological symptoms such as seizures and highlights the importance of long-term follow-up for post-thyroidectomy patients.

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Publication Details

Journal
Cureus
Published
2025-05-15
DOI
https://doi.org/10.7759/cureus.84167
Citations
1
Primary Topic
Thyroid and Parathyroid Surgery
Type
article
Field-Weighted Citation Impact
2.01
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A Rare Presentation of Hypocalcaemia-Induced Seizure Secondary to Late-Onset Post-Thyroidectomy Complication

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1 citations
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Thyroid and Parathyroid Surgery
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article

A Rare Presentation of Hypocalcaemia-Induced Seizure Secondary to Late-Onset Post-Thyroidectomy Complication

Shahid Ullah, Shamal Chandra Karmaker, Yameen Hamid, Md Al Amin Sarkar, Samarea Nowrin
article en
1 citations

Abstract

We report a rare case of late-onset hypocalcaemia presenting with seizure in a female patient, occurring approximately 25 years after a total thyroidectomy. Initial investigations ruled out intracranial pathology, and biochemical analysis confirmed severe hypocalcaemia. The patient responded to intravenous calcium gluconate infusion, with subsequent stabilisation on oral calcium therapy. Notably, the patient had been non-compliant with long-term calcium supplementation. This report underscores that chronic hypocalcaemia can manifest with acute neurological symptoms such as seizures and highlights the importance of long-term follow-up for post-thyroidectomy patients.

CureusVol. 17(5)
Maidstone and Tunbridge Wells NHS Trust (GB), Medway NHS Foundation Trust (GB), University of Edinburgh (GB)
Zero hunger
Openalex Percentile: Top 16%
Thyroid and Parathyroid Surgery
2.01
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