The aspartate superpathway in gut microbiota-related metabolic pathways mediates immune cell protection against COPD and IPF: a Mendelian randomization analysis
There is a causal link between the gut microbiota-related metabolic pathway, the aspartate superpathway, and IPF and COPD, where the influence is partially mediated by monocytes and cDCs. In clinical practice, we increase the focus on gut microbiota-mediated immune cells in relation to IPF and COPD.
Authors
- Kai Sun (ORCID: https://orcid.org/0000-0001-8866-8838)
- Mingjiong Zhang (ORCID: https://orcid.org/0000-0003-1416-2839)
- Jun Ma (ORCID: https://orcid.org/0000-0002-0903-5547)
- Lei Chen (ORCID: https://orcid.org/0000-0002-7382-8306)
- Qin Li (ORCID: https://orcid.org/0000-0001-7942-6685)
- Yu Han (ORCID: https://orcid.org/0000-0003-1462-1118)
- Jie Pan (ORCID: https://orcid.org/0000-0001-7817-0198)
- Haoyan Chen (ORCID: https://orcid.org/0000-0001-7208-3181)
- Shenghua Zhang (ORCID: https://orcid.org/0000-0002-6804-5446)
- Shuangshuang Wu (ORCID: https://orcid.org/0000-0003-4478-4823)
- Yanzhi Feng
Institutions
- Nantong University (CN)
- Yale University (US)
- Affiliated Hospital of Nantong University (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Aging
- Published
- 2025-05-15
- DOI
- https://doi.org/10.18632/aging.206250
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical University