Recommendations of the World Health Organization on Depressive Disorders in Human Health and Modern Pharmacotherapeutic Approaches to Optimizing Antidepressant Programs in the Alcohol Addiction Clinic

The article highlights the current recommendations of the World Health Organization (WHO) on the optimization of antidepressant programs. Based on global WHO studies conducted in 36 countries with different income levels, it is proven that the low level of recognition and treatment of depression and anxiety disorders leads to significant socio-economic losses. Particular attention is paid to losses for households, employers, and states, as well as insufficient financing of mental health even in high-income countries. The economic feasibility of investments in mental health is substantiated, through treatment that includes psychotherapy, drug therapy or their combination with the support of WHO mhGAP recommendations. The relationship of depression with other non-communicable diseases and the risk of suicidal behavior is separately considered. In a practical context, cases of depressive disorders among workers are analyzed, in conditions of military operations, economic instability and substance abuse. The importance of compliance with labor legislation in the context of mental health protection is described. A clinical approach to the complex therapy of depression of alcoholic origin in the post-abstinence period with the use of trazodone and cocarnitine is proposed, which demonstrates effectiveness in overcoming pathological craving for alcohol and stabilizing the psycho-emotional state. The results of the study indicate the feasibility of long-term active and supportive therapy to prevent relapses.