A Prospective Exploratory Study of Functional Immunity Assessed by Pretreatment Interferon Gamma Release Assay in Relation to Different Systemic Therapies in Patients With Advanced-Stage NSCLC
Patients with advanced-stage NSCLC exhibited reduced lymphocyte function, and patients with driver mutations correlated to less exhausted lymphocyte. IGRA demonstrates potential as a clinical tool for assessing immune function in these patients.
Authors
- Yung‐Hung Luo (ORCID: https://orcid.org/0000-0002-4194-162X)
- Tsu‐Hui Shiao
- Han-Jhih Chang
- Chao‐Hua Chiu (ORCID: https://orcid.org/0000-0001-8401-2356)
- Hsin‐Yi Huang (ORCID: https://orcid.org/0000-0003-1217-4131)
- Chi‐Lu Chiang (ORCID: https://orcid.org/0000-0003-1093-0669)
- Hui‐Chun Huang (ORCID: https://orcid.org/0000-0002-7384-6838)
- Yuh-Min Chen
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Medical University Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- JTO Clinical and Research Reports
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1016/j.jtocrr.2025.100845
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education
- Taipei Medical University
- Taipei Veterans General Hospital