Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology
In our Italian SSc cohort, DUs were significantly associated with the presence of puffy fingers, high revEUSTR-AI, and ATA seropositivity. Noteworthy, immunosuppressive treatments were associated with a low rate of DU, suggesting that they might contribute to the prevention of these harmful manifestations. Key Points • Digital ulcers were significantly associated with the presence of puffy fingers, high disease activity, and anti-Scl70 seropositivity. • Immunosuppressive treatments were associated with a low rate of digital ulcers, suggesting that they might contribute to the prevention of these harmful manifestations.
Authors
- Alarico Ariani (ORCID: https://orcid.org/0000-0003-1428-6102)
- Edoardo Rosato (ORCID: https://orcid.org/0000-0002-7417-8093)
- Francesca Ingegnoli (ORCID: https://orcid.org/0000-0002-6727-1273)
- Federica Lumetti (ORCID: https://orcid.org/0000-0003-4671-7982)
- Amelia Spinella (ORCID: https://orcid.org/0000-0003-4941-8507)
- Rosario Foti (ORCID: https://orcid.org/0000-0002-7301-8362)
- Elena Generali (ORCID: https://orcid.org/0000-0002-5898-1767)
- Giuseppina Abignano (ORCID: https://orcid.org/0000-0002-1479-0133)
- Greta Pellegrino (ORCID: https://orcid.org/0000-0002-1762-0770)
- Fabio Cacciapaglia (ORCID: https://orcid.org/0000-0001-7479-4462)
- Federica Furini (ORCID: https://orcid.org/0000-0002-0295-1913)
- Florenzo Iannone (ORCID: https://orcid.org/0000-0003-0474-5344)
- Ilenia De Andres
- Gian Domenico Sebastiani (ORCID: https://orcid.org/0000-0003-2969-6649)
- Anna Maria Iuliano
- Franco Franceschini (ORCID: https://orcid.org/0000-0003-3678-6124)
- Simone Parisi (ORCID: https://orcid.org/0000-0003-4496-8315)
- Silvia Laura Bosello (ORCID: https://orcid.org/0000-0002-4837-447X)
- Lorenzo Dagna (ORCID: https://orcid.org/0000-0002-7428-315X)
- Carlo Salvarani (ORCID: https://orcid.org/0000-0001-5426-5133)
- Luca Magnani (ORCID: https://orcid.org/0000-0002-7534-0785)
- Martina Orlandi (ORCID: https://orcid.org/0000-0001-6784-2235)
- Corrado Campochiaro (ORCID: https://orcid.org/0000-0001-6806-3794)
- Simone Barsotti (ORCID: https://orcid.org/0000-0002-4864-4505)
- Marcello Govoni (ORCID: https://orcid.org/0000-0003-0499-5773)
- Riccardo Cuoghi Costantini (ORCID: https://orcid.org/0000-0002-9116-5198)
- Marco Matucci‐Cerinic (ORCID: https://orcid.org/0000-0002-9324-3161)
- Dilia Giuggioli (ORCID: https://orcid.org/0000-0002-0041-3695)
- Alessandro Giollo (ORCID: https://orcid.org/0000-0001-9355-7673)
- Francesco Girelli (ORCID: https://orcid.org/0000-0002-6075-9989)
- Giuseppa Pagano Mariano (ORCID: https://orcid.org/0000-0003-4176-9206)
- Andrea Doria (ORCID: https://orcid.org/0000-0003-0548-4983)
- Giuseppe Murdaca (ORCID: https://orcid.org/0000-0002-6403-6905)
- Salvatore D’Angelo (ORCID: https://orcid.org/0000-0002-7442-1110)
- Ilaria Cavazzana (ORCID: https://orcid.org/0000-0002-2757-7120)
- Silvia Bellando-Randone (ORCID: https://orcid.org/0000-0002-5926-6263)
- Elisa Visalli (ORCID: https://orcid.org/0000-0002-8213-5528)
- Licia Vultaggio
- Valeria Riccieri (ORCID: https://orcid.org/0000-0002-7507-5483)
- Gianna Mennillo
- Edoardo Cipolletta (ORCID: https://orcid.org/0000-0002-6881-8197)
- Giacomo Davide De Luca (ORCID: https://orcid.org/0000-0002-5306-7714)
- Rossella De Angelis (ORCID: https://orcid.org/0000-0001-5169-3511)
- Veronica Codullo (ORCID: https://orcid.org/0000-0003-2557-8514)
- Carlo Iandoli
- Gianluca Bagnato (ORCID: https://orcid.org/0000-0002-7594-8520)
- Maria De Santis (ORCID: https://orcid.org/0000-0002-3196-1336)
- Enrico Fusaro (ORCID: https://orcid.org/0000-0001-9888-2563)
- Giovanni Zanframundo (ORCID: https://orcid.org/0000-0001-5042-1282)
- Gerolamo Bianchi (ORCID: https://orcid.org/0009-0009-1380-6146)
- Clara Lisa Peroni
- Maria Grazia Lazzaroni (ORCID: https://orcid.org/0000-0002-1860-6866)
- Giovanni Ciano
- Antonietta Gigante (ORCID: https://orcid.org/0000-0002-2015-765X)
- Lorenzo Beretta (ORCID: https://orcid.org/0000-0002-6529-6258)
- Erika Pigatto (ORCID: https://orcid.org/0000-0002-7593-7813)
- Giovanna Cuomo (ORCID: https://orcid.org/0000-0002-4292-3589)
- Ennio Lubrano (ORCID: https://orcid.org/0000-0001-6189-5328)
- Alessandra Della Rossa (ORCID: https://orcid.org/0000-0002-3165-1565)
- Gianluigi Bajocchi (ORCID: https://orcid.org/0000-0002-6430-800X)
- Elisabetta Zanatta (ORCID: https://orcid.org/0000-0002-4845-5413)
- Serena Guiducci
- Franco Cozzi (ORCID: https://orcid.org/0000-0003-3627-3927)
- Clodoveo Ferri (ORCID: https://orcid.org/0000-0002-0840-5817)
- Cecilia Agnes
- Maurizio Santi Caminiti
- P. Di Giorgio
- Marta Saracco
Institutions
- University of Pisa (IT)
- University of Messina (IT)
- University of Verona (IT)
- University of Modena and Reggio Emilia (IT)
- Marche Polytechnic University (IT)
- University of Molise (IT)
- Humanitas University (IT)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- University of Ferrara (IT)
- University of Basilicata (IT)
- University of Pavia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale San Paolo (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Maggiore (IT)
- Ospedale San Carlo (IT)
- Istituto Clinico Sant'Ambrogio (IT)
- Biogem (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
- Ospedale San Bassiano (IT)
- Arcispedale Sant'Anna (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Torino e-district (IT)
- Policlinico Universitario di Catania (IT)
- Ospedale di Parma (IT)
- Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT)
- Guglielmo da Saliceto Hospital (IT)
- Sydney Local Health District (AU)
- Azienda di Rilievo Nazionale ed Alta Specializzazione (IT)
- Policlinico San Matteo Fondazione (IT)
- University of the Sacred Heart (JP)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Florence (IT)
- University of Bari Aldo Moro (IT)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Clinical Rheumatology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s10067-025-07449-1
- Citations
- 2
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Università Degli Studi di Modena e Reggio Emila