Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology

In our Italian SSc cohort, DUs were significantly associated with the presence of puffy fingers, high revEUSTR-AI, and ATA seropositivity. Noteworthy, immunosuppressive treatments were associated with a low rate of DU, suggesting that they might contribute to the prevention of these harmful manifestations. Key Points • Digital ulcers were significantly associated with the presence of puffy fingers, high disease activity, and anti-Scl70 seropositivity. • Immunosuppressive treatments were associated with a low rate of digital ulcers, suggesting that they might contribute to the prevention of these harmful manifestations.

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Publication Details

Journal
Clinical Rheumatology
Published
2025-05-15
DOI
https://doi.org/10.1007/s10067-025-07449-1
Citations
2
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
Field-Weighted Citation Impact
2.94

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article

Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology

Alarico Ariani, Edoardo Rosato, Francesca Ingegnoli, Federica Lumetti et al.
2 citations
Clinical Rheumatology
Systemic Sclerosis and Related Diseases
2.94
article

Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology

Alarico Ariani, Edoardo Rosato, Francesca Ingegnoli, Federica Lumetti, Amelia Spinella, Rosario Foti, Elena Generali, Giuseppina Abignano, Greta Pellegrino, Fabio Cacciapaglia, Federica Furini, Florenzo Iannone, Ilenia De Andres, Gian Domenico Sebastiani, Anna Maria Iuliano, Franco Franceschini, Simone Parisi, Silvia Laura Bosello, Lorenzo Dagna, Carlo Salvarani, Luca Magnani, Martina Orlandi, Corrado Campochiaro, Simone Barsotti, Marcello Govoni, Riccardo Cuoghi Costantini, Marco Matucci‐Cerinic, Dilia Giuggioli, Alessandro Giollo, Francesco Girelli, Giuseppa Pagano Mariano, Andrea Doria, Giuseppe Murdaca, Salvatore D’Angelo, Ilaria Cavazzana, Silvia Bellando-Randone, Elisa Visalli, Licia Vultaggio, Valeria Riccieri, Gianna Mennillo, Edoardo Cipolletta, Giacomo Davide De Luca, Rossella De Angelis, Veronica Codullo, Carlo Iandoli, Gianluca Bagnato, Maria De Santis, Enrico Fusaro, Giovanni Zanframundo, Gerolamo Bianchi, Clara Lisa Peroni, Maria Grazia Lazzaroni, Giovanni Ciano, Antonietta Gigante, Lorenzo Beretta, Erika Pigatto, Giovanna Cuomo, Ennio Lubrano, Alessandra Della Rossa, Gianluigi Bajocchi, Elisabetta Zanatta, Serena Guiducci, Franco Cozzi, Clodoveo Ferri, Cecilia Agnes, Maurizio Santi Caminiti, P. Di Giorgio, Marta Saracco
article en
2 citations

Abstract

In our Italian SSc cohort, DUs were significantly associated with the presence of puffy fingers, high revEUSTR-AI, and ATA seropositivity. Noteworthy, immunosuppressive treatments were associated with a low rate of DU, suggesting that they might contribute to the prevention of these harmful manifestations. Key Points • Digital ulcers were significantly associated with the presence of puffy fingers, high disease activity, and anti-Scl70 seropositivity. • Immunosuppressive treatments were associated with a low rate of digital ulcers, suggesting that they might contribute to the prevention of these harmful manifestations.

Clinical RheumatologyVol. 44(7)
University of Pisa (IT), University of Messina (IT), University of Verona (IT), University of Modena and Reggio Emilia (IT), Marche Polytechnic University (IT), University of Molise (IT), Humanitas University (IT), University of Padua (IT), Vita-Salute San Raffaele University (IT), University of Milan (IT), University of Ferrara (IT), University of Basilicata (IT), University of Pavia (IT), Agostino Gemelli University Polyclinic (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Ospedale San Paolo (IT), Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT), Ospedale Maggiore (IT), Ospedale San Carlo (IT), Istituto Clinico Sant'Ambrogio (IT), Biogem (IT), Ospedale G.B. Morgagni - L.Pierantoni (IT), Ospedale San Bassiano (IT), Arcispedale Sant'Anna (IT), University of Campania "Luigi Vanvitelli" (IT), Torino e-district (IT), Policlinico Universitario di Catania (IT), Ospedale di Parma (IT), Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT), Guglielmo da Saliceto Hospital (IT), Sydney Local Health District (AU), Azienda di Rilievo Nazionale ed Alta Specializzazione (IT), Policlinico San Matteo Fondazione (IT), University of the Sacred Heart (JP), Carlo Forlanini Hospital (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), University of Florence (IT), University of Bari Aldo Moro (IT), University of Brescia (IT), Sapienza University of Rome (IT)
Università Degli Studi di Modena e Reggio Emila
Openalex Percentile: Top 10%
Systemic Sclerosis and Related Diseases
2.94
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