Depot medroxyprogesterone acetate (DMPA)-associated early-onset osteoporotic fracture

Evidence shows that intramuscular depot medroxyprogesterone acetate (DMPA) negatively affects BMD by inhibiting the hypothalamic-pituitary-ovarian axis. However, the risk of bone fragility fracture from DMPA remains uncertain because of paucity of data on fracture incidence. Herein, we present a case of a premenopausal woman with an unusual hip fracture and a history of prolonged use of intramuscular DMPA contraception. Our case also highlights that the patient's clinical presentation is essential for interpreting genetic sequencing results.