Visceral fat, cardiovascular risk factors and quality of life in lupus activity categorised via complement C3
Inactive patients with SLE exhibited more adverse cardiovascular risk markers compared with active patients categorised by complement C3, even when glucocorticoid administration was accounted for. Additionally, this research highlights the potential influence of fibrinogen as well as metabolic and sociodemographic factors on disease activity. These findings emphasise the need for personalised precision management strategies such as measurement of fibrinogen levels and insulin resistance and sociodemographic considerations that address both cardiovascular risk and overall lifestyle plus exposome in patients with SLE and may partly explain SLE activity evolution.
Authors
- Andrea Higuera‐Gómez (ORCID: https://orcid.org/0000-0002-8680-6704)
- María Martínez‐Urbistondo (ORCID: https://orcid.org/0000-0003-1761-0617)
- Raquel Castejón (ORCID: https://orcid.org/0000-0002-9765-0303)
- Begoña de Cuevillas (ORCID: https://orcid.org/0009-0004-1317-1703)
- Susana Mellor‐Pita
- Víctor Moreno‐Torres (ORCID: https://orcid.org/0000-0002-9798-4514)
- J. Alfredo Martínéz (ORCID: https://orcid.org/0000-0001-5218-6941)
- Amanda Cuevas‐Sierra (ORCID: https://orcid.org/0000-0003-2631-2566)
- Juan-Antonio Vargas
Institutions
- Madrid Institute for Advanced Studies (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Universidad Internacional De La Rioja (ES)
- IMDEA Food (ES)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/lupus-2024-001423
- Citations
- 2
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Comunidad de Madrid
- Instituto de Salud Carlos III