ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis
Our study reveals that ECM1 is a critical regulator in MASH, modulating lipid peroxidation by maintaining PCBP1-mediated intracellular iron homeostasis. Targeting ECM1 to restore PCBP1-dependent iron homeostasis may offer a novel therapeutic avenue for MASH.
Authors
- Pengfei Pang
- Lei Bai (ORCID: https://orcid.org/0000-0001-8968-3386)
- Jingsong Li (ORCID: https://orcid.org/0000-0002-1064-637X)
- Bing Sun (ORCID: https://orcid.org/0000-0001-5917-3094)
- Qizhen Du (ORCID: https://orcid.org/0000-0003-2969-2840)
- Fuquan Jin
- Wen Ling Chen (ORCID: https://orcid.org/0000-0002-6839-8890)
- Zhiyang Ling (ORCID: https://orcid.org/0000-0001-8873-6773)
- Weiguo Fan (ORCID: https://orcid.org/0000-0002-2382-5473)
- Yong Hao (ORCID: https://orcid.org/0000-0001-7487-9327)
- Yadong Fu (ORCID: https://orcid.org/0000-0002-4133-6067)
- Danyan Zhang (ORCID: https://orcid.org/0000-0002-0233-494X)
- Shuangfeng Chen
- Rui Li (ORCID: https://orcid.org/0000-0001-8353-6772)
- Liyan Ma
- Liang Zhao (ORCID: https://orcid.org/0000-0002-7543-6322)
- Guoli Du
- Chunyan Yi (ORCID: https://orcid.org/0000-0002-3630-0924)
- Houkun Lv
- Ayiguzhali Abulitipu
- Yaguang Zhang
- Shaliyan Tuerxunmaimaiti
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- ShanghaiTech University (CN)
- Bozhou People's Hospital (CN)
- Center for Excellence in Molecular Cell Science (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1097/hep.0000000000001402
- Citations
- 7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.48