Proinflammatory cytokine-induced alpha cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism
Long-term cytokine exposure of human islet MTs created a type 1 diabetes-like phenotype with impaired low-glucose-induced glucagon secretion. This cytokine-induced alpha cell impairment was partially restored by [D-Ala<sup>2</sup>]-GIP with or without liraglutide, or by tirzepatide.
Authors
- Sayro Jawurek (ORCID: https://orcid.org/0009-0002-4821-5935)
- Kristine Henriksen (ORCID: https://orcid.org/0000-0001-8932-5933)
- Alexandra C. Title (ORCID: https://orcid.org/0009-0004-9289-0836)
- Bolette Hartmann (ORCID: https://orcid.org/0000-0001-8509-2036)
- Joachim Størling (ORCID: https://orcid.org/0000-0002-7529-4264)
- Burçak Yesildag (ORCID: https://orcid.org/0000-0002-5638-8708)
- Filip K. Knop (ORCID: https://orcid.org/0000-0002-2495-5034)
- Chantal Rufer (ORCID: https://orcid.org/0000-0002-7314-6364)
- Jens Juul Holst (ORCID: https://orcid.org/0000-0001-6853-3805)
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Novo Nordisk (Denmark) (DK)
- Novo Nordisk Foundation (DK)
- Gentofte Hospital (DK)
- Inspire (CH)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s00125-025-06425-3
- Citations
- 4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Steno Diabetes Center Copenhagen
- Københavns Universitet