Proteomic-based biomarker discovery reveals panels of diagnostic biomarkers for early identification of heart failure subtypes
We identified candidate proteins linked to HFpEF and HFrEF in a longitudinal HF progressor cohort and validated them in a community-based cohort. Adding these proteins to BNP led to a significant improvement in HF subtype prediction. Study results have clinical implications for blood-based screening of HF subtypes using panels of biomarkers, particularly in resource-limited settings.
Authors
- Mark Ledwidge (ORCID: https://orcid.org/0000-0001-7391-2949)
- Kenneth McDonald (ORCID: https://orcid.org/0000-0001-8011-3301)
- Claire Tonry (ORCID: https://orcid.org/0000-0002-5830-3472)
- Chris Watson (ORCID: https://orcid.org/0000-0001-8749-0732)
- Narainrit Karuna (ORCID: https://orcid.org/0000-0002-4050-7469)
- J. Gallagher (ORCID: https://orcid.org/0000-0002-5564-2890)
- Nadezhda Glezeva (ORCID: https://orcid.org/0000-0003-2117-1186)
Institutions
- University College Dublin (IE)
- Queen's University Belfast (GB)
- St. Vincent's University Hospital (IE)
- Chiang Mai University (TH)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s12967-025-06563-7
- Citations
- 3
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Queen's University Belfast
- Queen's University
- Northern Ireland Chest Heart and Stroke