Boron appended Ru-NHC catalyzed selective deoxygenative hydrogenation of tertiary amides and desulfurization of thioamides
Herein, we disclosed a selective hydrogenation of tertiary amides and desulfurization of thioamides to amines with phenylsilane as a reductant, using a bifunctional Ru-NHC complex 1 appended with a Lewis acid in the secondary coordination sphere. The catalytic process was further utilized to synthesize biologically relevant amine drug molecules in good yields.
Authors
- Prosenjit Daw (ORCID: https://orcid.org/0000-0002-0272-3929)
- Rambabu Dandela (ORCID: https://orcid.org/0000-0002-2764-782X)
- Raju Sharma
- Gowtham Kenguva (ORCID: https://orcid.org/0000-0002-1032-4039)
Institutions
- Institute of Chemical Technology (IN)
- Indian Institute of Science Education and Research Berhampur (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00399g
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Science and Engineering Research Board