Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins

The results revealed that Klotho null mutation leads to retinal degeneration characterized by functional impairments, gliosis, and amyloid-beta and hyperphosphorylated tau protein deposition in the retina. Klotho protein function is, therefore, mandatory for the maintenance of a healthy retina. The mouse Klotho null mutation may be used as a study model for age-related retinal degeneration and Alzheimer's disease.