The effects of systemic adropin administration on biochemical and morphological effects in diabetic nephropathy: a rat model study

The aim of the study was to investigate the biochemical and morphological effects of systemic adropin adminis- tration on renal tissue in streptozotocin-induced diabetic nephropathy in rats. The animals were divided into 4 groups as follows: control, adropin, diabetes, diabetes+adropin. The diabetic groups received a single dose of intraperitoneal streptozotocin (65 mg/kg). The fasting blood glucose level for diabetes was defined as at least 250 mg/dl. Eight weeks after administration of streptozotocin and/or the streptozotocin solvent to the adropin groups, 450 nmol/kg adropin was administered twice daily as an intraperitoneal injection for 10 days. The results of our study indicate that adro- pin administration has a significant impact on the adverse effects of diabetes on renal tissue. In particular, adropin administration resulted in a notable reduction in the high tissue total oxidant status, glomerular diameter, collagen fiber density, and vascular endothelial growth factor immunoreactivity observed in the diabetic group. These findings suggest that adropin has the potential to be a valuable therapeutic agent in reducing oxidative stress and improving histological and immunohistochemical changes in diabetic nephropathy.