2-Dodecyl-6-methoxycyclohexa-2,5-dien-1,4-dione alleviates liver fibrosis and improves intestinal flora and bile acid metabolism
Our study suggests that DMDD alleviates liver fibrosis by inhibiting the TGF-β/Smad signaling pathway, restoring gut microbiota homeostasis, and balancing bile acid metabolism.
Authors
- Junming Xu (ORCID: https://orcid.org/0000-0002-9687-5551)
- Ruixi Li (ORCID: https://orcid.org/0000-0002-4338-445X)
- Thi Thai Hoa Pham (ORCID: https://orcid.org/0009-0007-6753-6829)
- Yongfei He (ORCID: https://orcid.org/0000-0001-8813-1416)
- Jicai Wang (ORCID: https://orcid.org/0000-0001-7980-4412)
- Xianjie Shi (ORCID: https://orcid.org/0000-0001-7712-2258)
- Qiang Tao (ORCID: https://orcid.org/0000-0002-6357-5552)
- Guangquan Zhang (ORCID: https://orcid.org/0000-0002-1721-3358)
- Hang Zhai
- Shengjie Hong
Institutions
- Sun Yat-sen University (CN)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-16
- DOI
- https://doi.org/10.3389/fphar.2025.1581138
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation