Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in rats
This study demonstrates that taVNS significantly improves LPS-induced depressive-like behaviors by modulating peripheral pro- and anti-inflammatory cytokine levels and inhibiting the activation of the NF-κB signaling pathway in the prefrontal cortex. These findings highlight the critical role of taVNS in the regulation of the peripheral-central inflammation network and provide theoretical support for the development of taVNS-based non-invasive neuromodulation therapies.
Authors
- Junying Wang (ORCID: https://orcid.org/0000-0002-0143-8325)
- Peijing Rong (ORCID: https://orcid.org/0000-0002-7288-2319)
- Yifei Wang (ORCID: https://orcid.org/0000-0003-0956-2459)
- Jinling Zhang (ORCID: https://orcid.org/0000-0002-6017-7751)
- Zijie Chen (ORCID: https://orcid.org/0000-0001-6603-050X)
- Haohan Zhu (ORCID: https://orcid.org/0009-0009-4009-3137)
- Xingke Song (ORCID: https://orcid.org/0000-0002-1958-1832)
- Yu Wang (ORCID: https://orcid.org/0000-0002-9029-1846)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1536056
- Citations
- 9
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 7.58
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences