Spatial navigation entropy suggests allocentric dysfunction in PPPD
Our findings suggest that PPPD involves deficits in allocentric spatial navigation, likely due to predictive coding errors and impaired internal model updating, rather than sensory input dysfunction. Increased gaze scanning may reflect compensatory mechanisms for spatial uncertainty. Notably, VR immersion did not alter navigation performance, suggesting visuo-vestibular conflict is not the primary driver of PPPD-related spatial deficits. These findings offer new insights into PPPD as a disorder of spatial cognition, opening avenues for novel diagnostic and therapeutic approaches.
Authors
- Pablo Billeke (ORCID: https://orcid.org/0000-0003-4261-0678)
- Hayo A. Breinbauer (ORCID: https://orcid.org/0000-0002-3278-065X)
- Camilo Arévalo-Romero (ORCID: https://orcid.org/0000-0003-2348-5656)
- Claudio Lavín (ORCID: https://orcid.org/0000-0002-1683-657X)
- Paul H. Délano (ORCID: https://orcid.org/0000-0003-2588-4757)
- Karen Villarroel (ORCID: https://orcid.org/0009-0006-6938-7807)
- Kevin Alarcón P. (ORCID: https://orcid.org/0009-0008-7291-9717)
- Felipe Faúndez
- Gustavo Vial
- Francisco Artus
Institutions
- Universidad del Desarrollo (CL)
- Clínica Alemana (CL)
- Universidad Autónoma de Chile (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- Instituto de Neurociencia Biomédica (CL)
- Hospital San Borja Arriarán (CL)
- University of Chile (CL)
- Federico Santa María Technical University (CL)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-05-16
- DOI
- https://doi.org/10.3389/fneur.2025.1599307
- Citations
- 1
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Agencia Nacional de Investigación y Desarrollo