Association between lipid accumulation product and endometriosis: A cross-sectional study from NHANES 1999–2006

The association of lipid accumulation product (LAP) and the likelihood of endometriosis prevalence has not been previously mentioned. The research aimed to assess the possible potential association between LAP and endometriosis in nationwide research. This cross-sectional analysis was conducted on 2,216 participants selected from the National Health and Nutrition Examination Survey (NHANES) in the 1999-2006 cycles. Logistic regression and stratified analysis by age, race, level of education, BMI, marital status, PIR, glycohemoglobin, drinking, and smoking status were used to analyze the association of the LAP index and odds of endometriosis prevalence. Moreover, smoothed curve fitting was used to evaluate the relevancy of LAP and endometriosis. The multivariate logistic regression model showed a positive association between ln LAP and endometriosis. This trend remained after a full adjustment (odds ratio = 1.37, 95% confidence interval:1.08-1.75, P = 0.010). Compared to the minimum ln LAP quartile, participants in the highest ln LAP had a 93% higher chance of endometriosis incidence (odds ratio = 1.93, 95% confidence interval: 1.08-3.46, P = 0.027). After conducting subgroup analysis and interaction testing, it was found that this positive association was most prominent among women aged 35 years and above and participants with glycohemoglobin≥6%. This nationwide study suggested that an elevated ln LAP was related to an increased endometriosis prevalence. Therefore, LAP may be a valuable tool for predicting the occurrence of endometriosis. Follow-up studies are critical to assess the association between LAP and odds of endometriosis prevalence and explain the potential mechanisms of this relationship.