Advances in the Investigation of the Oncological Functions and its Target Therapy of Interleukin-1 Receptor-associated Kinase 1 (IRAK1)

Interleukin-1 receptor-associated kinase 1 (IRAK1) plays as a pivotal regulator within the innate immune signaling and inflammatory processes. Being a critical component in many signaling pathways, emerging evidence strongly suggests the involvement of IRAK1 in the pathophysiology of cancers, thereby rendering it an attractive target for therapeutic intervention. Notably, selective IRAK1-inhibitory molecules have been identified, opening promising avenues for the therapy of tumor. In this review, we also delve into the challenges and future prospects in this field, emphasizing the importance of gaining a deeper understanding of IRAK1 regulation in tumors and the potential of combination therapies targeting IRAK1.