Disruption of the caspase-1/IL-1β axis alleviates myocardial Ischemia/Reperfusion injury via improvement of mitochondrial homeostasis and reduction of Pyroptosis
Overall, activating the Caspase-1/IL-1β axis by myocardial I/R injury causes mitochondrial homeostasis imbalance, pyroptosis, and the consequent cardiomyocyte injury.
Authors
- Chaoying Hu (ORCID: https://orcid.org/0000-0002-0116-4387)
- Shan Xiao (ORCID: https://orcid.org/0000-0002-3667-7262)
- Yuan Xu (ORCID: https://orcid.org/0000-0003-0861-5897)
- Lei He (ORCID: https://orcid.org/0000-0003-2573-4302)
- Yuan Fang (ORCID: https://orcid.org/0000-0002-2064-1038)
- Xiang Peng (ORCID: https://orcid.org/0000-0002-4256-5435)
- YingXing Wu
Institutions
- Nanchang University (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Clinical and Experimental Hypertension
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1080/10641963.2025.2506619
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Jiangxi Province