Different types of crystalluria in patients with bone and joint tissue pathology: Hematological and biochemical profiles

Crystalluria, as a sign of dysmetabolic nephropathy, has been associated with bone and joint tissue pathology. The aim of the study was to reveal the structure of crystalluria in patients with bone and joint tissue pathology and to investigate the characteristics of biochemical parameters according to the type of dysmetabolic nephropathy. In this study, common blood analyses and biochemical parameters were investigated. Individuals with bone and joint tissue pathology demonstrated prevalence of hyperoxaluria (59%) with less frequency of uraturia (25.7%) and phosphaturia (15.1%). Hyperoxaluria was associated with high incidence of ligamentum ruptures and bone fractures (21.6%). The patients with hyperoxaluria showed presence of eosinophilia, increased levels of platelets, leukocytes, erythrocyte sedimentation rate, C-reactive protein and serum alkaline phosphatase, whereas the patients with uraturia demonstrated decreased level of platelets and increased level of serum glucose, uric acid and creatinine. Patients with phosphaturia demonstrated increased serum alanine aminotransferase. The results presented in this paper revealed the differences in biochemical parameters of patients with different types of crystalluria, suggesting the necessity of its control to improve the prognosis of the treatment of patients with bone and joint tissue pathology.