Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease
Our findings suggest that, unlike p-tau181 and p-tau231, plasma p-tau217 consistently aligns with cognitive status in A+ individuals and better reflects CSF biomarker abnormalities, reducing discrepancies between clinical and biochemical findings. Its association with baseline and future memory decline highlights its diagnostic and prognostic value, particularly when CSF analysis or PET is unavailable.
Authors
- Lene Pålhaugen
- Ragnhild Eide Skogseth (ORCID: https://orcid.org/0000-0001-6688-9955)
- Michael Turton
- Berglind Gísladóttir (ORCID: https://orcid.org/0000-0002-1787-3006)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Bjørn‐Eivind Kirsebom (ORCID: https://orcid.org/0000-0002-1413-9578)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Knut Waterloo (ORCID: https://orcid.org/0000-0003-3447-8312)
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Yara Yakoub (ORCID: https://orcid.org/0000-0002-4769-7162)
- Tormod Fladby (ORCID: https://orcid.org/0000-0002-9984-9797)
- Geir Bråthen (ORCID: https://orcid.org/0000-0003-3224-7983)
- Jonas Alexander Jarholm
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Arvid Rongve (ORCID: https://orcid.org/0000-0002-0476-4134)
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Per Selnes (ORCID: https://orcid.org/0000-0001-5131-9757)
- Peter Harrison
- J Gundersen
Institutions
- University of Science and Technology of China (CN)
- University Hospital of North Norway (NO)
- University of Wisconsin–Madison (US)
- King's College London (GB)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Douglas Mental Health University Institute (CA)
- Stavanger University Hospital (NO)
- Akershus University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Privatsykehuset Haugesund (NO)
- Sorbonne Université (FR)
- St Olav's University Hospital (NO)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Haraldsplass Diakonale Sykehus (NO)
- Institut du Cerveau (FR)
- University of Bergen (NO)
- University College London (GB)
- UiT The Arctic University of Norway (NO)
- University of Gothenburg (SE)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1212/wnl.0000000000213676
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24