Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inhibiting ferroptosis in ischemic stroke
Our study suggests that DGAT1 inhibition may enhance β-oxidation and mitochondrial function, thereby increasing Gpx4 levels, suppressing ferroptosis, and ultimately exerting neuroprotective effects in ischemic stroke.
Authors
- Yuxin Lin (ORCID: https://orcid.org/0000-0001-6543-0317)
- Xia Wang (ORCID: https://orcid.org/0000-0002-1684-7076)
- Youjie Zeng (ORCID: https://orcid.org/0000-0003-3842-1815)
- Songhua Chen (ORCID: https://orcid.org/0000-0002-0858-3664)
- Siyi Zhang
- Si Cao
- Ren Guo (ORCID: https://orcid.org/0000-0002-3930-6846)
- Wen Ouyang (ORCID: https://orcid.org/0000-0002-8596-2537)
- Wenxiang Qing (ORCID: https://orcid.org/0000-0002-0550-8618)
- Heng Yang (ORCID: https://orcid.org/0000-0002-6729-9735)
- Huilin Xu
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s10020-025-01255-w
- Citations
- 4
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Natural Science Foundation of China