Ejection Fraction Recovery in Peripartum Cardiomyopathy (PPCM) Patients After Cardio-Obstetric Intervention [ID 984]

INTRODUCTION: Peripartum cardiomyopathy (PPCM) incidence varies widely based on maternal health factors such as hypertension and advanced age, race, and access to routine obstetric care. Nearly 50% of PPCM patients are Black, more than 38% live in the least advantaged, first quartile, and around 48% live in the South. There is limited understanding of left ventricle ejection fraction (LVEF) recovery rates stratified according to Area Deprivation Index (ADI) residence quartile. We hypothesized lower ejection fraction recovery in patients living in areas of worse socioeconomic disadvantage. METHODS: Fifty-three patients with a diagnosis of PPCM were seen in the cardio-obstetrics program between June 2022 and May 2024. Left ventricle ejection fraction recovery was tracked during 3-, 6-, 12-, and/or 24-month follow-up appointments. Independent, two-tailed t-test analyses were utilized to identify differences in ejection fraction recovery based upon residence in national and state quartiles. RESULTS: During 2 years of follow-up, 47% (n=25) of patients demonstrated some LVEF recovery, with 28% (n=15) experiencing recovery above the LVEF rate greater than 45% threshold by the first 3-month follow-up visit. Furthermore, results of independent, two-tailed t-test analysis revealed statistically significant difference in ejection fraction recovery based upon ADI ranking for both national and state quartiles. CONCLUSIONS/IMPLICATIONS: Peripartum cardiomyopathy presents a rare, yet severe and worsening, threat to maternal health, affected by geographic, socioeconomic, and maternal health factors. Left ventricle ejection fraction recovery is significantly associated with residence in both national and state ADI quartiles. Routine cardio-obstetric follow-up presents a novel opportunity for PPCM surveillance and risk reduction.