The Effect of Race/Ethnicity on the Association of Vitamin D Levels and Leiomyomas [ID 832]

INTRODUCTION: Low vitamin D levels have been associated with an increased incidence of leiomyoma (LM). However, these findings have been based on small samples, thus making comparison in different ethnicities/races problematic. METHODS: We employed a large multi-institutional database (EPIC, COSMOS). Recorded demographics and CPT and ICD-10 coding were used to identify cohorts. Our study population included patients who had vitamin D assayed during the last 10 years. Next, comparison cohorts based on race/ethnicity, presence/absence of LMs, and normal/low vitamin D levels were created. Overall odds ratios (ORs) were calculated based on LMs and vitamin D levels and corrected for multiple measurements. RESULTS: In the study period, 3,476,864 females between the ages of 26 and 51 years (71.2% White [W], 16.8% Black [B], 10.3% Hispanic [H], and 5.7% Asian [A]) had vitamin D assessed. More than half (51.7%) had low vitamin D levels with an overall LM incidence of 8.3%. Blacks were more likely to have LM (OR 3.14, P <.001) and/or a low vitamin D (OR 1.52, P <.001). Asians had the lowest risk of LM (OR 0.89, P <.001). There was an increase in LMs in individuals with low vitamin D (OR, W 1.32, B 1.27, A 1.24 [ P <.001]). This relationship was not noted in Hispanics (OR 0.89, P <.001). CONCLUSIONS/IMPLICATIONS: Low vitamin D levels are widespread. This larger study (3.4 million patients) confirms the association of LM and low vitamin D. The lack of this relationship in patients self-identified as Hispanic has not been previously reported and remains to be answered.