Cervical Polyp in Pregnancy: Risk of Preterm Labor? [ID 810]

INTRODUCTION: Cervical polyps noted during pregnancy have been associated with preterm birth (PTB). However, these studies have been limited by small sample size (less than 100) from single institutions. By employing a large multi-institution database to increase sample size, we hope to identify prenatal/antenatal complications associated with pregnancies with cervical polyps (PregCP). METHODS: A 1,500 hospital database (Epic, COSMOS) was utilized during a 10-year time period (September 2013 to September 2023). Demographics, pregnancy complication, and mode of delivery were recorded. The cases were compared to controls, which were randomly selected from the same time period (1:1 ratio). Comparisons were made using t-test, chi-squared, and adjusted for multiple measurements using Bonferroni correction. RESULTS: During the time period, 8,924,917 deliveries were reviewed with 2,274 containing a cervical polyp (0.026%). The PregCP were older than controls (32.2±5.5 versus 28.3±6.2 years, P <.001) and more often nulliparous (76.7% versus 68.6%, P <.001). They did not differ in body mass index, prior preterm birth, gestational age, twin pregnancies, or route of delivery. Complications including placental previa, preeclampsia, and postpartum hemorrhage were similar. Gestational diabetes was higher in PregCP (15.8% versus 11.4%, P <.001). Preterm delivery before 37 weeks or 34 weeks did not differ between groups. CONCLUSIONS/IMPLICATIONS: Cervical polyps in pregnancy are noted in older nulliparous women. The increased rate of gestational diabetes may have been related to older PregCP. However, unlike other smaller studies, we did not note higher rates of preterm birth, thus questioning this association in PregCP.