Polycystic Kidney Disease in Pregnancy and Obstetric Outcomes [ID 1340]

INTRODUCTION: Polycystic kidney disease (PKD) is a rare genetic condition. The purpose of our study is to evaluate the effect of PKD on obstetric outcomes. METHODS: A retrospective cohort study was performed using the population-based American database National Inpatient Sample. We identified all births between the years 2016 and 2021. The exposure group was defined as PKD, and the comparison group was all other births. Baseline characteristics were described and multivariable logistic regression, adjusted for maternal age, was used to assess associations between PKD and obstetric maternal and fetal outcomes. RESULTS: We identified 1,139 patients with PKD and 4,336,473 patients without PKD who gave birth between the years 2016 and 2021. The overall incidence of PKD was 26 per 100,000 births, with no significant increase over the study period ( P =.07). Compared with non-PKD patients, those with PKD were more often Caucasian, obese, and had preexisting hypertension. Polycystic kidney disease patients were more likely to deliver via cesarean (odds ratio 1.4 [95% CI, 1.2–1.5]) and were at greater risk of developing preeclampsia (2.4 [2.0–2.9]) and gestational diabetes (1.6 [1.3–1.9]). Polycystic kidney disease patients were also more likely to suffer from sepsis (3.5 [2.3–5.3]) and death (10.2 [2.5–40.7]). Neonates born from PKD patients were more likely to suffer from preterm birth (2.7 [2.4–3.1]), intrauterine growth restriction (1.8 [1.4–2.3]), and intrauterine fetal demise (1.7 [1.02–2.8]). CONCLUSIONS/IMPLICATIONS: Polycystic kidney disease patients and their fetuses/newborns are at a greater risk for obstetric complications and should be considered high-risk patients. As such, their pregnancies should be followed closely by obstetricians, nephrologists, and neonatologists.