Deciphering the role of acetylation-related gene NAT10 in colon cancer progression and immune evasion: implications for overcoming drug resistance
Leveraging SMR and multi-omics analysis, this study highlights the significant role of acetylation-related genes, particularly NAT10, in colon cancer. The findings suggest that acetylation modifications in epithelial cells contribute to immune evasion and cancer progression. NAT10 could serve as a promising biomarker and therapeutic target for early diagnosis and targeted therapy, offering new avenues for improving colon cancer treatment and patient outcomes.
Authors
- Yuheng Gu (ORCID: https://orcid.org/0000-0003-0209-3450)
- Xuancheng Zhou (ORCID: https://orcid.org/0009-0003-0700-9382)
- Hao Chi (ORCID: https://orcid.org/0000-0002-7898-2599)
- Xinting Sang (ORCID: https://orcid.org/0000-0003-1952-0527)
- J. Q. Zhang
- Binbin Wang (ORCID: https://orcid.org/0000-0003-2885-6428)
- Lai Jiang (ORCID: https://orcid.org/0000-0002-4639-8136)
- Xiaolin Zhong (ORCID: https://orcid.org/0000-0002-5831-2491)
- Shengke Zhang
- Yong Fu (ORCID: https://orcid.org/0009-0002-0078-5963)
- Chenglu Jiang
- Guanhu Yang
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Southwest Medical University (CN)
- Ohio University (US)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s12672-025-02617-w
- Citations
- 6
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 4.84