Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury <i>via</i> the miR-21/PTEN axis
GAS5 promotes neuronal apoptosis in SCI by binding to miR-21 and upregulating PTEN expression, inhibiting the AKT pathway. Targeting GAS5 may represent a novel therapeutic strategy for SCI.
Authors
- Zhongzheng Zhi
- Guanghui Xu (ORCID: https://orcid.org/0000-0001-9534-214X)
- Jian Kang (ORCID: https://orcid.org/0000-0002-3888-2462)
- Yingjie Wang (ORCID: https://orcid.org/0000-0003-1005-7900)
- Tao Liu (ORCID: https://orcid.org/0000-0003-0011-3016)
Institutions
- Tongji University (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- World Journal of Orthopedics
- Published
- 2025-05-16
- DOI
- https://doi.org/10.5312/wjo.v16.i5.106183
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00