EFFECTIVENESS OF TRIPLE THERAPY WITH SINGLE AND MULTIPLE INHALERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Introduction: Exacerbations of chronic obstructive pulmonary disease (COPD) contribute to 3 million annual deaths worldwide. Triple therapy (ICS + LABA + LAMA) helps reduce symptoms and exacerbation risk. Objective: To assess the effectiveness and clinical response of single versus multiple inhaler therapy in managing COPD. Methods: A pre-post study was conducted on two groups of COPD patients over 8 weeks. Group 1 (n=47) used a single inhaler, while Group 2 (n=45) used multiple inhalers. Outcomes were measured using the mMRC scale, blood eosinophil levels, and spirometry at weeks 2 and 8. Results: The single-inhaler group significantly reduced mMRC scores, with a median decrease from 4.00 to 2.00 (p<0.05). Eosinophil levels also decreased significantly in both groups, with a larger reduction in the single-inhaler group (p<0.05). Lung function improved in both groups, but no significant differences were found (p>0.05) in terms of time or between-group comparisons. Conclusion: Single-inhaler therapy reduced dyspnea and eosinophil levels more effectively than multiple inhalers. The effectiveness of single inhalers may be attributed to higher adherence due to ease of use.