Characteristics of polyclonal anti-interferon-gamma autoantibodies and novel diagnostic strategies: A prospective cohort study of new biomarkers
Patients with AIGA syndrome have abnormally elevated IgG levels, with IgG3 subtypes dominating. The disorder is characterized by the rapid acquisition of polyclonal AIGAs. The obtained AIGAs had a good neutralization capacity and potential as absolute quantitative biomarkers.
Authors
- Zhengtu Li (ORCID: https://orcid.org/0000-0001-5584-7223)
- Jinglu Yang
- Xue‐Zhong Yu (ORCID: https://orcid.org/0000-0002-1751-2884)
- Yangqing Zhan (ORCID: https://orcid.org/0000-0002-8935-4301)
- Shaoqiang Li (ORCID: https://orcid.org/0000-0001-9663-5358)
- Yan Wang (ORCID: https://orcid.org/0000-0003-2046-7604)
- Jing Liu (ORCID: https://orcid.org/0000-0002-2323-6492)
- Feng Ye (ORCID: https://orcid.org/0000-0002-5953-6024)
- Xidong Wang (ORCID: https://orcid.org/0009-0007-7312-0715)
- Hongling Liu (ORCID: https://orcid.org/0000-0003-1604-8036)
- Yongming Li
Institutions
- Sun Yat-sen University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100292
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China