Association of Metabolic Comorbidities With Fibrosis Severity and Fibrosis Regression in Patients With Chronic Hepatitis B
Presence of metabolic comorbidities in untreated CHB patients is associated with more severe liver fibrosis and, after initiation of antiviral therapy, with less fibrosis regression and a higher risk of fibrosis progression.
Authors
- Henry Lik‐Yuen Chan (ORCID: https://orcid.org/0000-0002-7790-1611)
- Lesley A. Patmore (ORCID: https://orcid.org/0000-0002-2911-2140)
- Leland J. Yee (ORCID: https://orcid.org/0000-0002-0369-5878)
- Bettina E. Hansen (ORCID: https://orcid.org/0000-0001-8307-3341)
- Keyur Patel (ORCID: https://orcid.org/0000-0002-4677-3127)
- Rong‐Nan Chien (ORCID: https://orcid.org/0000-0001-7656-4695)
- Teerha Piratvisuth (ORCID: https://orcid.org/0000-0002-5249-9208)
- Jordan J. Feld (ORCID: https://orcid.org/0000-0003-2640-2211)
- Marı́a Buti (ORCID: https://orcid.org/0000-0002-0732-3078)
- Milan J. Sonneveld (ORCID: https://orcid.org/0000-0002-9253-563X)
- Scott Fung (ORCID: https://orcid.org/0000-0003-0501-8800)
- Vedran Pavlovic (ORCID: https://orcid.org/0000-0002-9475-7201)
- Willem Pieter Brouwer (ORCID: https://orcid.org/0000-0001-8713-1481)
- Audrey Lau
- Edo J. Dongelmans (ORCID: https://orcid.org/0000-0003-2746-1643)
- Lisa M. van Velsen
- Harry L.A. Janssen
- Qing Xie
Institutions
- Universitat Autònoma de Barcelona (ES)
- Prince of Songkla University (TH)
- Chang Gung University (TW)
- Chinese University of Hong Kong (HK)
- University of Toronto (CA)
- Ruijin Hospital (CN)
- Erasmus MC (NL)
- Chang Gung Memorial Hospital (TW)
- Songklanagarind Hospital (TH)
- Roche (United Kingdom) (GB)
- Vall d'Hebron Hospital Universitari (ES)
- Gilead Sciences (United States) (US)
- Toronto Liver Centre (CA)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical Gastroenterology and Hepatology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1016/j.cgh.2025.04.024
- Citations
- 5
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Stichting voor Lever- en Maag-Darm Onderzoek