Endogenous Galectin-8 protects against Th17 infiltration and fibrosis following acute kidney injury
Endogenous Gal-8 does not significantly protect the kidney during the acute phase and is dispensable for cell proliferation and death in response to AKI. However, it is crucial in preventing maladaptive repair by regulating extracellular matrix homeostasis and mitigating fibrosis. Additionally, Gal-8 contributes to inflammation resolution by limiting persistent immune cell infiltration, particularly IL-17-secreting cells.
Authors
- Elisa Pérez-Moreno (ORCID: https://orcid.org/0000-0003-1697-1058)
- Rodrigo Pacheco (ORCID: https://orcid.org/0000-0001-8057-9806)
- Cristián A. Amador (ORCID: https://orcid.org/0000-0001-6802-6811)
- Andrea Soza (ORCID: https://orcid.org/0000-0003-3783-5231)
- Claudia Metz (ORCID: https://orcid.org/0000-0002-5093-3066)
- Fabián Segovia‐Miranda (ORCID: https://orcid.org/0000-0003-1546-0475)
- Alejandro Godoy (ORCID: https://orcid.org/0000-0002-8208-023X)
- Carolina Prado (ORCID: https://orcid.org/0000-0001-7015-9058)
- Teo Feuerhake (ORCID: https://orcid.org/0000-0002-7065-2309)
- Adely de la Peña (ORCID: https://orcid.org/0000-0002-2588-3925)
- J.M. Saez
- Alfonso González
- Tomás Toledo
- Francisca Pérez-Molina
- Lorena Azócar
- Sofía Espinoza (ORCID: https://orcid.org/0000-0001-6363-5896)
- Nicole Díaz-Valdivia
Institutions
- Pontificia Universidad Católica de Chile (CL)
- University of Concepción (CL)
- San Sebastián University (CL)
- Fundación Ciencia and Vida (CL)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s10020-025-01245-y
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico