Alcohol-induced bone loss driven by dysregulated spatial distribution of gut microbiota and PGD2-IL17 pathway-mediated osteoclast activation
This study demonstrates that alcohol-induced elevation of PGD2 is a key pathogenic factor in AOP. PGD2 accelerates bone loss by promoting osteoclast formation through the activation of Th17 cells. Furthermore, this study highlights the importance of investigating the spatial distribution of gut microbiota and metabolites, providing potential targets and novel strategies for the precise treatment of AOP and other diseases associated with external stimuli.
Authors
- Xiaopeng Jia (ORCID: https://orcid.org/0000-0002-8307-6689)
- Shicheng Luo (ORCID: https://orcid.org/0000-0001-5776-1319)
- Yujing Bi (ORCID: https://orcid.org/0000-0002-8309-2259)
- Gongzi Zhang (ORCID: https://orcid.org/0000-0002-6955-7021)
- Ruifu Yang (ORCID: https://orcid.org/0000-0003-3219-7269)
- Hang Guo (ORCID: https://orcid.org/0000-0001-8712-9787)
- Peng Ye (ORCID: https://orcid.org/0000-0002-8327-2241)
- Lihai Zhang (ORCID: https://orcid.org/0000-0003-3172-6309)
Institutions
- Nankai University (CN)
- Academy of Military Medical Sciences (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fmicb.2025.1551028
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61