Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations
Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was 12 days (IQR, 9-15); 59% were treated for >10 days. There was marked variability in treatment durations across hospitals.
Authors
- Jesse Sutton (ORCID: https://orcid.org/0000-0002-1476-1746)
- Sara M. Karaba (ORCID: https://orcid.org/0000-0001-8452-5549)
- Katelyn Quartuccio (ORCID: https://orcid.org/0000-0002-6658-9132)
- Pranita D. Tamma (ORCID: https://orcid.org/0000-0002-4143-6324)
- Anurag N. Malani (ORCID: https://orcid.org/0000-0002-0676-7451)
- Karen Howard
- Kelly E Pillinger (ORCID: https://orcid.org/0000-0003-2697-886X)
- Christopher McCoy (ORCID: https://orcid.org/0000-0003-1290-7761)
- Judianne Slish
- Timothy C Jenkins (ORCID: https://orcid.org/0000-0002-1029-7085)
- Drew Engers (ORCID: https://orcid.org/0000-0001-6636-5457)
- Jae Hyoung Lee (ORCID: https://orcid.org/0000-0002-6303-086X)
- Alok Gupta
Institutions
- Trinity Health (US)
- Johns Hopkins University (US)
- University of Utah (US)
- Johns Hopkins Medicine (US)
- Denver Health Medical Center (US)
- University of Rochester Medical Center (US)
- VA Salt Lake City Healthcare System (US)
- Highland Hospital (US)
- Lahey Medical Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1093/ofid/ofaf298
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00