Probiotic <i>Lactobacillus</i> Species Modulate Immune Responses During Vaginal Epithelial Cell Colonization
Overall, vaginal epithelial and downstream immune responses during co-cultivation with C. albicans and probiotic lactobacilli were mostly driven by specific bacterial species and their interactions with the vaginal epithelium. Therefore, the induction of "controlled" inflammation by probiotic lactobacilli may be beneficial to improve neutrophil function; however, whether this alleviates immunopathology warrants further investigation.
Authors
- Bernhard Hube (ORCID: https://orcid.org/0000-0002-6028-0425)
- Mark S. Gresnigt (ORCID: https://orcid.org/0000-0002-9514-4634)
- Marisa Valentine (ORCID: https://orcid.org/0000-0001-5627-3196)
- Diletta Rosati (ORCID: https://orcid.org/0000-0003-2992-2503)
- Axel Dietschmann (ORCID: https://orcid.org/0000-0002-0598-9714)
- Tim B Schille (ORCID: https://orcid.org/0009-0008-8296-5434)
- Mihai G. Netea
Institutions
- University of Bonn (DE)
- Radboud University Nijmegen (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- Life & Brain (Germany) (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1093/infdis/jiaf221
- Citations
- 5
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 5.92
Funders
- Freistaat Thüringen
- European Commission
- Deutsche Forschungsgemeinschaft
- European Society of Clinical Microbiology and Infectious Diseases
- Fonds Wetenschappelijk Onderzoek