Design and rationale of “a pragmatic approach to the investigation of stable chest pain: A UK, multicenter, randomized trial to assess patient outcomes, quality of life and cost effectiveness (CE-MARC 3)”
About 3,407 patients recruited and randomized by the end of February 2025 CONCLUSION: This trial will address whether, in patients with suspected cardiac chest pain, a strategy of personalized investigation according to pretest likelihood (PTL), compared to CTCA for allcomers, leads to improved patient outcomes, quality of life and cost-effectiveness.
Authors
- Guy Lloyd (ORCID: https://orcid.org/0000-0003-1958-6606)
- John Pierre Greenwood (ORCID: https://orcid.org/0000-0002-2861-0914)
- Deborah D. Stocken (ORCID: https://orcid.org/0000-0001-8031-1738)
- Gerry P McCann (ORCID: https://orcid.org/0000-0002-5542-8448)
- Nick Curzen (ORCID: https://orcid.org/0000-0001-9651-7829)
- Peter Swoboda (ORCID: https://orcid.org/0000-0001-7162-7079)
- Simon Walker (ORCID: https://orcid.org/0000-0002-5750-3691)
- Colin Berry (ORCID: https://orcid.org/0000-0002-4547-8636)
- Myka Ransom (ORCID: https://orcid.org/0000-0003-4359-8287)
- Andrew Kelion (ORCID: https://orcid.org/0000-0002-3636-4063)
- Chiara Bucciarelli‐Ducci (ORCID: https://orcid.org/0000-0002-2515-0852)
- Laura Jones
Institutions
- University of Leeds (GB)
- Baker Heart and Diabetes Institute (AU)
- Barts Health NHS Trust (GB)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Glenfield Hospital (GB)
- Golden Jubilee National Hospital (GB)
- John Radcliffe Hospital (GB)
- Harefield Hospital (GB)
- British Heart Foundation (GB)
- Essex Cardiothoracic Centre (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- NIHR Leicester Cardiovascular Biomedical Research Unit (GB)
- Oxford University Hospitals NHS Trust (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- University of York (GB)
Publication Details
- Journal
- American Heart Journal
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1016/j.ahj.2025.05.006
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- Heart Research UK