A phenome-wide association study of uterine fibroids reveals a marked burden of comorbidities
Overall, individuals with fibroids have a marked increase in comorbidities compared to those without fibroids. This approach to evaluate the health context of fibroids highlights the potential to understand fibroid etiology through studying the common biology of comorbid diagnoses and through disease networks.
Authors
- Todd L. Edwards (ORCID: https://orcid.org/0000-0003-4318-6119)
- Elizabeth A. Jasper (ORCID: https://orcid.org/0000-0003-2444-0951)
- Jacqueline A. Piekos (ORCID: https://orcid.org/0000-0002-7062-5052)
- Jacklyn N. Hellwege (ORCID: https://orcid.org/0000-0001-7479-0920)
- Eric S. Torstenson (ORCID: https://orcid.org/0000-0002-8434-7647)
- Brian S. Mautz (ORCID: https://orcid.org/0000-0003-3870-2932)
- Digna R. Velez Edwards (ORCID: https://orcid.org/0000-0001-5293-0056)
- Sarah A. Pendergrass (ORCID: https://orcid.org/0000-0002-0565-6522)
- Yanfei Zhang (ORCID: https://orcid.org/0000-0002-9222-7725)
- Sarah H. Jones (ORCID: https://orcid.org/0000-0002-2588-7264)
- Ming Ta Michael Lee (ORCID: https://orcid.org/0000-0003-1769-6895)
Institutions
- Vanderbilt University (US)
- EP Analytics (United States) (US)
- Geisinger Health System (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1038/s43856-025-00884-w
- Citations
- 1
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Vanderbilt University
- Vanderbilt Institute for Clinical and Translational Research
- National Institutes of Health
- National Cancer Institute
- National Center for Advancing Translational Sciences