Targeting interferon responses in juvenile dermatomyositis: Siglec-1 as an in vitro biomarker for JAK inhibitor efficacy
Siglec-1 is an easy and reliable in vitro marker for type I IFN responses. Its induction can be inhibited by JAKi. The type I IFN signature in JDM is likely predominantly driven by IFN-β. This assay holds promise for precision treatment strategies in JDM and other IFN-driven diseases.
Authors
- Joost Raaphorst (ORCID: https://orcid.org/0000-0002-3658-2001)
- Ellen Schatorjé
- Marc H.A. Jansen (ORCID: https://orcid.org/0000-0001-6969-8759)
- Sanne W Evers
- Femke van Wijk (ORCID: https://orcid.org/0000-0001-8343-1356)
- Darragh Duffy (ORCID: https://orcid.org/0000-0002-8875-2308)
- Eveline M. Delemarre (ORCID: https://orcid.org/0000-0002-4310-0998)
- Sylvia Kamphuis (ORCID: https://orcid.org/0000-0002-1964-352X)
- Brigitte Bader‐Meunier (ORCID: https://orcid.org/0000-0001-8476-8196)
- Annet van Royen‐Kerkhof (ORCID: https://orcid.org/0009-0009-6874-4421)
- Anneke J. van der Kooi (ORCID: https://orcid.org/0000-0002-5261-5512)
- Mathieu Paul Rodero (ORCID: https://orcid.org/0000-0002-1300-0187)
- Saskia R Veldkamp (ORCID: https://orcid.org/0000-0002-1626-353X)
- T. Moreau (ORCID: https://orcid.org/0009-0000-2965-0400)
- J. Merlijn van den Berg (ORCID: https://orcid.org/0000-0003-3026-2784)
- Petra C. E. Hissink Muller (ORCID: https://orcid.org/0000-0003-1610-8721)
- Wineke Armbrust
- Vincent Bondet
- Maud Reugebrink
Institutions
- Leiden University (NL)
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Sorbonne Paris Cité (FR)
- Emma Kinderziekenhuis (NL)
- Assistance Publique – Hôpitaux de Paris (FR)
- Amalia Kinderziekenhuis (NL)
- Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (FR)
- Beatrix Kinderziekenhuis (NL)
- Willem-Alexander Kinderziekenhuis (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Amsterdam University Medical Centers (NL)
- Wilhelmina Children's Hospital (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1093/rheumatology/keaf227
- Citations
- 5
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Sanofi
- Prinses Beatrix Spierfonds