RAS/RAF/MEK/MAPK signaling pathway as a therapeutic target in breast cancer: Emphasis on a novel carrier for tamoxifen and digestion behaviors.
Our findings pointed out the remarkable potential of TMX-loaded CNCs, derived from walnut shell, in suppressing the proliferation, migration, and invasion of breast cancer cells by quelling the RAS/RAF/MEK/MAPK signaling pathways. The gathered data approved the promising applicability of the obtained CNCs from walnut shell in the delivery system of anti-cancer drugs throughout pharmaceutical applications.
Authors
- Parisa Mokaberi (ORCID: https://orcid.org/0000-0002-5935-1302)
- Jamshidkhan Chamani (ORCID: https://orcid.org/0000-0003-2562-2458)
- Niloofar Mansouri
- Farzaneh Khojasteh
- Reza Taheri (ORCID: https://orcid.org/0009-0007-7356-7998)
- Zahra Modaresi
- Melika Daneshgar
- Mohammad Reza Saberi (ORCID: https://orcid.org/0000-0002-3450-9775)
Institutions
- Mashhad University of Medical Sciences (IR)
- Islamic Azad University, Mashhad (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ajp.2024.25253
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Islamic Azad University