Reductive Deuteration of Aldehydes/Ketones for the Synthesis of Monodeuterated Phosphinates and Derivatives Using D<sub>2</sub>O as the Nucleophilic Deuterium Source
The ideal deuteration, for organic synthetic chemists, might include the use of a cheap deuterium source, mild operating conditions, and diverse transformations. We developed an umpolung sequence for the reductive deuteration of aldehydes/ketones, affording synthetically useful monodeuterated phosphinates. The further one-pot transformation and plausible mechanism of this reaction were studied.
Authors
- Xiaochen Niu (ORCID: https://orcid.org/0000-0002-1104-1049)
- Yuanyuan Xie (ORCID: https://orcid.org/0000-0001-8482-9948)
- Hongwei Zhou (ORCID: https://orcid.org/0000-0001-8308-960X)
Institutions
- Jiaxing University (CN)
- Zhejiang Pharmaceutical College (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1021/acs.joc.5c00235
- Citations
- 1
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- National Natural Science Foundation of China