Isolated Skin Metastasis From Papillary Thyroid Carcinoma: A Rare Presentation

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy and is often characterized by a high rate of regional lymph node involvement. However, distant metastasis is uncommon, and cutaneous metastases are particularly rare, occurring in fewer than 0.1% of cases. This report presents an unusual case of isolated skin metastasis as the first manifestation of distant spread in PTC. The case highlights the diagnostic challenges associated with this rare presentation, explores potential mechanisms underlying cutaneous dissemination, and underscores the significance of a multidisciplinary approach to management. The findings emphasize the importance of long-term surveillance and meticulous pathological evaluation in patients with PTC, particularly in cases with atypical metastatic patterns.

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Publication Details

Journal
JCEM Case Reports
Published
2025-05-15
DOI
https://doi.org/10.1210/jcemcr/luaf106
Citations
2
Primary Topic
Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
2.09
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article

Isolated Skin Metastasis From Papillary Thyroid Carcinoma: A Rare Presentation

Naseem Eisa
2 citations
JCEM Case Reports
Cancer Diagnosis and Treatment
2.09
article

Isolated Skin Metastasis From Papillary Thyroid Carcinoma: A Rare Presentation

Naseem Eisa
article en
2 citations

Abstract

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy and is often characterized by a high rate of regional lymph node involvement. However, distant metastasis is uncommon, and cutaneous metastases are particularly rare, occurring in fewer than 0.1% of cases. This report presents an unusual case of isolated skin metastasis as the first manifestation of distant spread in PTC. The case highlights the diagnostic challenges associated with this rare presentation, explores potential mechanisms underlying cutaneous dissemination, and underscores the significance of a multidisciplinary approach to management. The findings emphasize the importance of long-term surveillance and meticulous pathological evaluation in patients with PTC, particularly in cases with atypical metastatic patterns.

JCEM Case ReportsVol. 3(7)
Community Partners (US), HealthPartners (US)
Openalex Percentile: Top 12%
Cancer Diagnosis and Treatment
2.09
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