APOE4 and chronic health risk factors are associated with sex-specific preclinical Alzheimer’s disease neuroimaging biomarkers
Findings suggest genetic and chronic health risk factors are associated with sex-specific AD neuroimaging biomarkers. Underlying sex-specific biological pathways may explain these findings. Our results highlight the importance of considering sex differences in neuroimaging studies and when developing effective interventions for AD prevention and risk reduction.
Authors
- Eric D. Vidoni (ORCID: https://orcid.org/0000-0001-5181-7131)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Genna Losinski
- Jonathan Clutton (ORCID: https://orcid.org/0000-0002-3593-4271)
- Mickeal N. Key (ORCID: https://orcid.org/0000-0002-7535-0107)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- Amber Watts (ORCID: https://orcid.org/0000-0002-8385-1091)
Institutions
- University of Kansas (US)
Publication Details
- Journal
- Frontiers in Global Women s Health
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fgwh.2025.1531062
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Eli Lilly and Company
- National Institutes of Health
- National Institute on Aging
- National Institute of General Medical Sciences