Tibetan medicine pain relieving plaster for treatment of knee osteoarthritis: protocol for a multi-center, randomized, and positive drug controlled trial
This methodologically robust randomized controlled trial will comprehensively characterize PRP's therapeutic potential in KOA management, specifically examining its impacts on core clinical manifestations (pain, mobility restriction, joint swelling) and patient-reported outcomes. The findings will inform evidence-based utilization of this approved Tibetan medicinal formulation in real-world clinical practice.
Authors
- Zhaolan Liu (ORCID: https://orcid.org/0000-0003-2992-1578)
- Min Zhao (ORCID: https://orcid.org/0000-0002-4551-043X)
- Xisheng Weng (ORCID: https://orcid.org/0000-0002-6021-1462)
- Kai Liu (ORCID: https://orcid.org/0000-0002-0413-8651)
- Zhenji Shen
- P. Y. Liu
- Yi Yuan (ORCID: https://orcid.org/0000-0002-1864-5718)
- Jian-rong Xie
- Kai-Lie Liu
- Jian‐Min Zuo (ORCID: https://orcid.org/0000-0002-5151-3370)
- Jian-Ping Liu (ORCID: https://orcid.org/0000-0003-4814-4284)
- Yingjie Wang (ORCID: https://orcid.org/0000-0003-1005-7900)
- Wei Qiang Wang (ORCID: https://orcid.org/0000-0002-1430-1360)
- Weiguo Wang (ORCID: https://orcid.org/0000-0002-9050-440X)
- Zhilong Shi (ORCID: https://orcid.org/0000-0003-2544-4743)
- Ai Guo (ORCID: https://orcid.org/0000-0003-2658-0106)
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Friendship Hospital (CN)
- Tibetan Traditional Medical College (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fmed.2025.1597183
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing University of Chinese Medicine