Regulatory B cells promote the immunosuppressive microenvironment and progression of clear cell renal cell carcinoma
This study underscores the pivotal role of Bregs in promoting immune suppression and poor prognosis in ccRCC. The CMLBregS model offers a robust prognostic tool, identifies patients less likely to benefit from immunotherapy, and highlights IRF4 as a potential alternative target. These findings provide a foundation for future strategies aimed at overcoming Breg-mediated immunosuppression in ccRCC.
Authors
- Yonghao Chen (ORCID: https://orcid.org/0000-0003-0205-1816)
- Aihetaimujiang Anwaier (ORCID: https://orcid.org/0000-0002-0859-5171)
- Siqi Zhou (ORCID: https://orcid.org/0000-0002-0668-340X)
- Dingwei Ye (ORCID: https://orcid.org/0000-0002-6761-5195)
- Qintao Ge (ORCID: https://orcid.org/0000-0001-5040-6699)
- Xi Tian (ORCID: https://orcid.org/0000-0003-1965-0647)
- Jiahe Lu (ORCID: https://orcid.org/0000-0002-3555-1991)
- Hailiang Zhang (ORCID: https://orcid.org/0000-0002-8050-2494)
- Wenhao Xu (ORCID: https://orcid.org/0000-0002-0660-9162)
- Shiqi Ye (ORCID: https://orcid.org/0009-0007-9070-443X)
Institutions
- Qingdao University (CN)
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- West China Medical Center of Sichuan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
Publication Details
- Journal
- Immunotherapy Advances
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/immadv/ltaf013
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Municipal Health Bureau
- National Science and Technology Major Project