Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model
We discovered two melanocyte clusters with distinct fates and a pro-inflammatory micro-environment with CXCL16-CXCR6 axis activation of antigen-presenting cells and other innate immunocytes that might provide new insights into the pathogenesis of stress-induced vitiligo.
Authors
- Yongkai Yu
- Jiawei Lu (ORCID: https://orcid.org/0000-0003-1199-8526)
- Yan Lü (ORCID: https://orcid.org/0000-0002-5893-6114)
- Ming Lu (ORCID: https://orcid.org/0000-0001-8018-8389)
- Yifei Feng (ORCID: https://orcid.org/0000-0002-5222-7106)
- Ziyu Li (ORCID: https://orcid.org/0000-0001-5580-4979)
- Hang Yao
- Yujie Zheng (ORCID: https://orcid.org/0000-0002-8678-5253)
- Xuechen Cao
- Pei Tu
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s10020-025-01236-z
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province