Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets
This pilot study highlights the potential role of NGS analysis on solid biopsy in the assessment of the mutational profile of lung NET. A comparison of germline and somatic mutations is critical to identifying putative tumor driver mutations. In perspective, the enrichment of a subpopulation of cancer cells in the blood, with one or more specific mutations, is information of enormous clinical relevance, either for prognosis or therapeutic decisions. Translational studies on large prospective series are required to establish the role of liquid biopsy in lung NET.
Authors
- Andrea Vecchione (ORCID: https://orcid.org/0000-0002-5497-6856)
- Marcello Maugeri‐Saccà (ORCID: https://orcid.org/0000-0003-2287-9581)
- Rossella Mazzilli (ORCID: https://orcid.org/0000-0001-6707-3413)
- Antongiulio Faggiano (ORCID: https://orcid.org/0000-0002-9324-3946)
- Diana Bellavia (ORCID: https://orcid.org/0000-0001-5728-2537)
- Ludovica Ciuffreda (ORCID: https://orcid.org/0000-0002-7964-7119)
- Anna La Salvia (ORCID: https://orcid.org/0000-0002-5020-8657)
- Rita Mancini (ORCID: https://orcid.org/0000-0002-5491-2449)
- Mohsen Ibrahim (ORCID: https://orcid.org/0000-0002-9288-2359)
- Stefano Scalera (ORCID: https://orcid.org/0000-0001-5192-5917)
- Giulia Pecora (ORCID: https://orcid.org/0000-0001-7099-706X)
- Maurizio Fanciulli (ORCID: https://orcid.org/0000-0002-5281-4191)
- Stefano Telese (ORCID: https://orcid.org/0009-0001-5516-2395)
- Camilla Mancini (ORCID: https://orcid.org/0009-0002-1839-133X)
- Alessandra Siciliani (ORCID: https://orcid.org/0000-0002-0376-9697)
- Francesca De Nicola (ORCID: https://orcid.org/0000-0002-2187-7544)
- Claudia De Vitis (ORCID: https://orcid.org/0000-0001-8899-2347)
- Virginia Zamponi (ORCID: https://orcid.org/0000-0002-2422-9673)
- Massimiliano Mancini (ORCID: https://orcid.org/0000-0001-7465-2229)
- Andrea Maria Isidori (ORCID: https://orcid.org/0000-0002-9037-5417)
Institutions
- Istituto Superiore di Sanità (IT)
- CTO Andrea Alesini (IT)
- National Cancer Institute (MY)
- Tumori Foundation (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s12967-025-06442-1
- Citations
- 2
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- European Commission
- Sapienza Università di Roma
- Associazione Italiana per la Ricerca sul Cancro
- Ministero dell'Università e della Ricerca