A lactate-related tSNE signature defines prognostic subtypes of bladder cancer and reveals LINC01094-mediated VIM stabilization in metastasis and drug resistance
This comprehensive analysis of lactate-related genes reveals how this gene signature may shape the tumor microenvironment and affect BLCA patient prognosis. Additionally, our data suggest that targeting LINC01094 with antisense oligonucleotides (ASOs) could reduce BLCA cell metastasis and enhance their sensitivity to chemotherapy.
Authors
- Qingliu He
- Dage Fan
- Yao Pan (ORCID: https://orcid.org/0000-0002-4114-8509)
- Wei Zhuang (ORCID: https://orcid.org/0009-0008-9907-1576)
- Pu Zhang
- Hegan Zhang
- Wanli Yu
- Fangzhen Cai
Institutions
- Fujian Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1593523
- Citations
- 2
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.01