Characterization of the transcriptional cellular response in midgut tissue of temephos-resistant Aedes aegypti larvae
In this study, we investigated transcriptome-level changes maintained in a temephos-resistant Ae. aegypti colony under continuous and prolonged selection pressure. Our results indicate that metabolic resistance might involve a larger and more significant number of detoxification enzymes, with different functional roles, than previously shown with other mechanisms, also contributing to the resistance phenotype in the Ae. aegypti RecR colony.
Authors
- Osvaldo P. de Melo Neto (ORCID: https://orcid.org/0000-0001-5402-7346)
- Maria J. R. Bezerra (ORCID: https://orcid.org/0000-0002-6507-8795)
- Tatiany Patrícia Romão (ORCID: https://orcid.org/0000-0002-5296-0543)
- Elisama Helvécio (ORCID: https://orcid.org/0000-0001-9275-5555)
- Antônio Mauro Rezende (ORCID: https://orcid.org/0000-0003-4775-1779)
- Constância Flávia Junqueira Ayres
- Maria Alice Varjal de Melo Santos
Institutions
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1186/s13071-025-06675-5
- Citations
- 2
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz