Comparative analysis of oral microbiome in saliva samples of oral leukoplakia, proliferative leukoplakia and oral squamous cell carcinoma
Distinct microbial patterns differentiate OL from PVL and OSCC, with OL being different from PVL and OSCC, suggesting progressive microbial dysbiosis in malignant transformation. These findings support the potential of oral microbiome profiling as a non-invasive diagnostic and prognostic tool in oral oncology and highlight the need for longitudinal studies to establish causal relationships.
Authors
- Rossella Intini (ORCID: https://orcid.org/0000-0001-7239-5302)
- Leticia Bagán (ORCID: https://orcid.org/0000-0002-4499-1999)
- Giulio Fortuna (ORCID: https://orcid.org/0000-0001-7655-3523)
- Hervé Sroussi
- José Vicente Bagán Sebastián (ORCID: https://orcid.org/0000-0002-0295-2916)
- Sol Balsells
Institutions
- Brigham and Women's Hospital (US)
- University of Salerno (IT)
- Universitat de València (ES)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Dana-Farber Cancer Institute (US)
- Dana-Farber Brigham Cancer Center (US)
Publication Details
- Journal
- Frontiers in Oral Health
- Published
- 2025-05-14
- DOI
- https://doi.org/10.3389/froh.2025.1600090
- Citations
- 5
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.33
Funders
- Ministerio de Ciencia e Innovación